Turn on the slow cooker to High to preheat.
Heat 1 tbsp oil in a large skillet. Season the cubed London broil with salt and pepper, then brown on all sides, 8–10 minutes. Transfer beef to the slow cooker.
In a small bowl, mix the chili powder, cumin, oregano, and smoked paprika with ¼ cup beer to make a paste.
Add the tomato paste to the hot slow cooker and let it bloom for 1–2 minutes, stirring. Stir in the remaining beer.
In the same skillet, add the remaining 1 tbsp oil and sauté the onion and jalapeños with a pinch of salt until softened, about 5 minutes.
Add the garlic and cook 1–2 minutes more.
Stir the spice paste into the skillet vegetables and cook 1–2 minutes to toast.
Transfer the sautéed mixture to the slow cooker.
Add tomatoes and beans.
Add water or broth to reach your preferred chili consistency (start with ~1½ cups).
Stir well and taste; season with salt & pepper.
Cook on High for 6 hours (or Low for 8–9 hours) until the beef is very tender.
If the chili is thinner than you like, remove the lid for the last 30 minutes or stir in a quick slurry (see Notes).
Ladle into bowls and top with cheese, onions, jalapeños, and chips or a slice of cornbread.